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Cell division control protein 4
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Cell division control protein 4 : ウィキペディア英語版
Cell division control protein 4

Cdc4 (cell division control protein 4) is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which acts as a mediator of ubiquitin transfer to target proteins, leading to their subsequent degradation via the ubiquitin-proteasome pathway. Cdc4 targets primarily cell cycle regulators for proteolysis. It serves the function of an adaptor that brings target molecules to the core SCF complex.
Cdc4 was originally identified in the model organism ''Saccharomyces cerevisiae''.
CDC4 gene function is required at G1/S and G2/M transitions during mitosis and at various stages during meiosis.〔

== Homologues ==
The human homologue of the cdc4 gene is called FBXW7. The corresponding gene product is the F-box/WD repeat-containing protein 7.
In the nematode ''C. elegans'', the homologue to Cdc4 is F-box/WD repeat-containing protein sel-10.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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